Licht-im-Terrarium: Literaturdatenbank
Licht-im-Terrarium: Literaturdatenbank |
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Ouweland, J. V. D. M. W. (2016). Analysis of vitamin d metabolites by liquid chromatography-tandem mass spectrometry. TrAC Trends in Analytical Chemistry, 84, 117–130. Added by: Sarina (02/08/2022, 16:03) Last edited by: Sarina (26/09/2022, 12:37) |
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| Resource type: Journal Article DOI: https://doi.org/10.1016/j.trac.2016.02.005 ID no. (ISBN etc.): 0165-9936 BibTeX citation key: Ouweland2016 View all bibliographic details  |
Categories: Englisch = English Keywords: Vitamin D = Vitamin D Creators: Ouweland Collection: TrAC Trends in Analytical Chemistry |
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| Abstract |
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Measurement of vitamin D has increased significantly over the last years due to its involvement not only in calcium homeostasis, but also in the pathogenesis of various autoimmune- and infectious diseases. In the majority of studies, emphasis has been on 25-hydroxyvitamin D, which is regarded the best indicator of vitamin D status, whereas recently more interest has arisen in a combined measurement of multiple clinically relevant vitamin D metabolites. LC-MS/MS is a powerful technique allowing simultaneous determination of various vitamin D metabolites covering a broad dynamic range. Multi-panel LC-MS/MS assays are likely to enhance future investigations regarding the optimal combination of metabolites for the assessment of vitamin D sufficiency as well as help us in gaining better understanding of vitamin metabolism in health and disease. This article reviews recent advances in the quantification of the major vitamin D metabolites by LC-MS/MS and their application in clinical research.
Added by: Sarina |