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van den Ouweland, J. M. W., Vogeser, M., & Bächer, S. (2013). Vitamin d and metabolites measurement by tandem mass spectrometry. Reviews in Endocrine and Metabolic Disorders, 14(2), 159–184. 
Added by: Sarina (2022-08-02 15:51:40)   
Resource type: Journal Article
DOI: 10.1007/s11154-013-9241-0
BibTeX citation key: vandenOuweland2013
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Categories: Englisch = English
Keywords: Vitamin D = Vitamin D
Creators: Bächer, van den Ouweland, Vogeser
Collection: Reviews in Endocrine and Metabolic Disorders
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The prevalence of vitamin D deficiency in the general population has become a major public health problem. Vitamin D deficiency might have significant consequences not only to bone health but possibly to autoimmune-, infectious and cardiovascular disease. This has resulted in increased clinical testing for 25-hydroxyvitamin D (25(OH)D) in serum, as circulating 25(OH)D is regarded as the best indicator of adequate exposure to sunlight and dietary intake of vitamin D. There are reportedly over 50 vitamin D metabolites of which 25(OH)D and 1,25(OH)2D are well known to provide clinical information. More recently, there is increasing interest in measuring the C3-epimer of 25(OH)D, which has shown to contribute significantly to the 25(OH)D concentration, particularly in infant populations, and in 24,25(OH)2D, a major catabolite of 25(OH)D metabolism. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is an analytical tool that allows the specific determination of all relevant vitamin D metabolites, with the potential of performing multiple analyte analysis in a single experimental setting, creating a vitamin D profile. This article reviews recent advances in the quantification of vitamin D metabolites using LC-MS/MS.
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