Licht-im-Terrarium: Literaturdatenbank
Licht-im-Terrarium: Literaturdatenbank |
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Berson, D. M., Dunn, F. A., & Takao, M. (2002). Phototransduction by retinal ganglion cells that set the circadian clock. Science, 295(5557), 1070–1073. Added by: Sarina (2013-01-22 15:13:49) |
| Resource type: Journal Article DOI: 10.1126/science.1067262 BibTeX citation key: Berson2002 View all bibliographic details  |
Categories: Englisch = English Keywords: Chronobiologie = Chronobiology, Netzhaut = Retina Creators: Berson, Dunn, Takao Collection: Science |
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| Abstract |
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Light synchronizes mammalian circadian rhythms with environmental time by modulating retinal input to the circadian pacemaker—the suprachiasmatic nucleus (SCN) of the hypothalamus. Such photic entrainment requires neither rods nor cones, the only known retinal photoreceptors. Here, we show that retinal ganglion cells innervating the SCN are intrinsically photosensitive. Unlike other ganglion cells, they depolarized in response to light even when all synaptic input from rods and cones was blocked. The sensitivity, spectral tuning, and slow kinetics of this light response matched those of the photic entrainment mechanism, suggesting that these ganglion cells may be the primary photoreceptors for this system.
Added by: Sarina |