Licht-im-Terrarium: Literaturdatenbank
Licht-im-Terrarium: Literaturdatenbank |
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Hewison, M. (2011). An update on vitamin d and human immunity. Clinical Endocrinology, Added by: Sarina (2011-11-09 11:36:03) |
| Resource type: Journal Article DOI: 10.1111/j.1365-2265.2011.04261.x BibTeX citation key: Hewison2011 View all bibliographic details  |
Categories: Englisch = English Keywords: Vitamin D = Vitamin D Creators: Hewison Collection: Clinical Endocrinology |
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| Abstract |
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In the last five years there has been a remarkable change in our understanding of the health benefits of vitamin D. The classical actions of vitamin D as a determinant of mineral metabolism and rachitic bone disease have been expanded to include a broader role in skeletal homeostasis and prevalent bone disorders such as osteoporosis. However, it is the non-skeletal functions of vitamin D that have attracted most attention. Although, pluripotent responses to vitamin D have been recognized for many years, our new perspective on non-classical vitamin D function stems from two more recent concepts. The first is that impaired, vitamin D status is common to many populations across the globe. This has prompted studies to explore the health impact of sub-optimal circulating levels of vitamin D, with association studies linking vitamin D ‘insufficiency’ to several chronic health problems including autoimmune and cardiovascular disease, hypertension and common cancers. In support of a broader role for vitamin D in human health, studies in vitro and using animal models have highlighted immunomodulatory and anti-cancer effects of vitamin D that appear to depend on localized activation of vitamin D. The conclusion from these reports is that many non-classical actions of vitamin D are independent of conventional vitamin D endocrinology and are therefore more sensitive to variations in vitamin D status. The current review summarizes these developments, with specific reference to the newly-identified effects of vitamin D on the immune system, but also highlights the challenges in translating these observations to clinical practice. Keywords: vitamin D; CYP27B1; vitamin D receptor; toll-like receptor; monocyte; neutrophil; T-cell; cathelicidin; tuberculosis Added by: Sarina |