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D'Agostini, F., Caimo, A., De Filippi, S. & De Flora, S. (1999) Induction and prevention of micronuclei and chromosomal aberrations in cultured human lymphocytes exposed to the light of halogen tungsten lamps. Mutagenesis, 14 433–436. 
Added by: Sarina (03 Oct 2013 15:45:21 UTC)   
Resource type: Journal Article
DOI: 10.1093/mutage/14.4.433
BibTeX citation key: DAgostini1999
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Categories: Englisch = English
Keywords: Gl├╝hlampe = Incandescent Lamp, Ultraviolett = Ultraviolet
Creators: Caimo, D'Agostini, De Filippi, De Flora
Collection: Mutagenesis
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Previous studies have shown that the light emitted by halogen tungsten lamps contains UV radiation in the UV-A, UV-B and UV-C regions, induces mutations and irreparable DNA damage in bacteria, enhances the frequency of micronuclei in cultured human lymphocytes and is potently carcinogenic to the skin of hairless mice. The present study showed that the light emitted by an uncovered, traditional halogen lamp induces a significant, dose-related and time-related increase not only in micronuclei but also in chromosome-type aberrations, such as breaks, and even more in chromatid-type aberrations, such as isochromatid breaks, exchanges and isochromatid/chromatid interchanges, all including gaps or not, in cultured human lymphocytes. All these genotoxic effects were completely prevented by shielding the same lamp with a silica glass cover, blocking UV radiation. A new model of halogen lamp, having the quartz bulb treated in order to reduce the output of UV radiation, was considerably less genotoxic than the uncovered halogen lamp, yet induction of chromosomal alterations was observed at high illuminance levels.
Added by: Sarina  
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