Licht-im-Terrarium: Literaturdatenbank
Licht-im-Terrarium: Literaturdatenbank |
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Holick, M. F. (2002). Vitamin d. Clinical Reviews in Bone and Mineral Metabolism, 1(3), 181–207. Added by: Sarina (2010-10-19 17:55:56) |
| Resource type: Journal Article ID no. (ISBN etc.): 1534-8644 BibTeX citation key: Holick2002 View all bibliographic details  |
Categories: Englisch = English Keywords: Vitamin D = Vitamin D Creators: Holick Collection: Clinical Reviews in Bone and Mineral Metabolism |
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| Abstract |
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Vitamin D evolved for the development and maintenance of a healthy vertebrate skeleton. Vitamin D (1,25-dihydroxyvitamin D) maintains serum calcium and phosphorus levels in a physiologic range for skeleton mineralization. Vitamin D increases intestinal calcium absorption, stimulating osteoblast function and mobilizing osteoclast precursor cells to enhance bone calcium mobilization. Most vitamin D for the human requirement comes from exposure to sunlight. Sunscreen use, aging, and an increase in latitude or skin pigmentation dramatically reduce the cutaneous synthesis of vitamin D3. Vitamin D deficiency has been linked to increased risk of many chronic diseases, including diabetes, cancer, hypertension, and heart disease. There is strong evidence that vitamin D plays a role in immunomodulation, cellular proliferative activity regulation, and renin production downregulation. Thus, vigilance to prevent vitamin D deficiency by the measurement of serum 25-hydroxyvitamin D is important for overall health and well-being. Although the recommended adequate intake for vitamin D is 200, 400, and 600 international units (IUs) for ages 0–50, 51–70, and 71+ yr, respectively, in the absence of exposure to adequate sunlight, the requirement is at least 1000 IUs of vitamin D. Responsible sun exposure will guarantee vitamin D sufficiency. Eating and drinking foods fortified with vitamin D, such as milk and orange juice, also provides some of the vitamin D requirement.
Added by: Sarina |