Licht-im-Terrarium: Literaturdatenbank
Licht-im-Terrarium: Literaturdatenbank |
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Cantorna, M. T. (2006). Vitamin d and its role in immunology: multiple sclerosis, and inflammatory bowel disease. Progress in Biophysics and Molecular Biology, 92(1), 60–64. Added by: Sarina (2010-01-08 21:51:22) |
| Resource type: Journal Article BibTeX citation key: Cantorna2006 View all bibliographic details  |
Categories: Englisch = English Keywords: Ultraviolett = Ultraviolet, Vitamin D = Vitamin D Creators: Cantorna Collection: Progress in Biophysics and Molecular Biology |
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| Abstract |
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Autoimmune diseases like multiple sclerosis (MS) and inflammatory bowel disease (IBD) occur because of an inappropriate immune-mediated attack against self-tissue. Analyses of genetically identical twins shows that besides genetics there are important environmental factors that contribute to MS and IBD development. Vitamin D availability due to sunshine exposure or diet may play a role in the development of MS and IBD. Compelling data in mice show that vitamin D and signaling through the vitamin D receptor dictate the outcome of experimental MS and IBD. Furthermore, the evidence points to the direct and indirect regulation of T cell development and function by vitamin D. In the absence of vitamin D and signals delivered through the vitamin D receptor, auto reactive T cells develop and in the presence of active vitamin D (1,25(OH)2D3 ) and a functional vitamin D receptor the balance in the T cell response is restored and autoimmunity avoided.
Added by: Sarina |