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Burt, L. A., Billington, E. O., Rose, M. S., Raymond, D. A., Hanley, D. A. & Boyd, S. K. (2019) Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial. JAMA, 322 736–745. 
Added by: Sarina (05 Oct 2022 11:04:00 UTC)   
Resource type: Journal Article
DOI: 10.1001/jama.2019.11889
ID no. (ISBN etc.): 0098-7484
BibTeX citation key: Burt2019
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Categories: Englisch = English
Creators: Billington, Boyd, Burt, Hanley, Raymond, Rose
Collection: JAMA
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Popularity index: 18.5%
Meine Sichtweise (Keine vollständige Zusammenfassung des Artikels! Meine Meinung muss nicht mit der Meinung der Autoren übereinstimmen! Bitte lesen Sie auch die Originalarbeit!)     

Eine hohe tägliche Vitamin-D3-Dosis (4000 IU, 10000 IU) erhöht die Häufigkeit von Hyperkalzurie (zu viel Kalzium im Urin) und verringert die Knochendichte. 


Added by: Sarina  
Abstract
{Few studies have assessed the effects of daily vitamin D doses at or above the tolerable upper intake level for 12 months or greater, yet 3% of US adults report vitamin D intakes of at least 4000 IU per day.To assess the dose-dependent effect of vitamin D supplementation on volumetric bone mineral density (BMD) and strength.Three-year, double-blind, randomized clinical trial conducted in a single center in Calgary, Canada, from August 2013 to December 2017, including 311 community-dwelling healthy adults without osteoporosis, aged 55 to 70 years, with baseline levels of 25-hydroxyvitamin D (25[OH]D) of 30 to 125 nmol/L.Daily doses of vitamin D3 for 3 years at 400 IU (n = 109), 4000 IU (n = 100), or 10 000 IU (n = 102). Calcium supplementation was provided to participants with dietary intake of less than 1200 mg per day.Co-primary outcomes were total volumetric BMD at radius and tibia, assessed with high resolution peripheral quantitative computed tomography, and bone strength (failure load) at radius and tibia estimated by finite element analysis.Of 311 participants who were randomized (53% men; mean [SD] age, 62.2 [4.2] years), 287 (92%) completed the study. Baseline, 3-month, and 3-year levels of 25(OH)D were 76.3, 76.7, and 77.4 nmol/L for the 400-IU group; 81.3, 115.3, and 132.2 for the 4000-IU group; and 78.4, 188.0, and 144.4 for the 10 000-IU group. There were significant group × time interactions for volumetric BMD. At trial end, radial volumetric BMD was lower for the 4000 IU group (−3.9 mg HA/cm3 [95% CI, −6.5 to −1.3]) and 10 000 IU group (−7.5 mg HA/cm3 [95% CI, −10.1 to −5.0]) compared with the 400 IU group with mean percent change in volumetric BMD of −1.2% (400 IU group), −2.4% (4000 IU group), and −3.5% (10 000 IU group). Tibial volumetric BMD differences from the 400 IU group were −1.8 mg HA/cm3 (95% CI, −3.7 to 0.1) in the 4000 IU group and −4.1 mg HA/cm3 in the 10 000 IU group (95% CI, −6.0 to −2.2), with mean percent change values of −0.4% (400 IU), −1.0% (4000 IU), and −1.7% (10 000 IU). There were no significant differences for changes in failure load (radiu
Added by: Sarina  
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