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Dixon, K. M., Norman, A. W., Sequeira, V. B., Mohan, R., Rybchyn, M. S., Reeve, V. E., Halliday, G. M. & Mason, R. S. (2011) 1α,25(OH)2-Vitamin D and a Nongenomic Vitamin D Analogue Inhibit Ultraviolet Radiation–Induced Skin Carcinogenesis. Cancer Prevention Research, 4 1485–1494. 
Added by: Sarina (09 Sep 2022 12:02:35 UTC)   
Resource type: Journal Article
DOI: 10.1158/1940-6207.CAPR-11-0165
ID no. (ISBN etc.): 1940-6207
BibTeX citation key: Dixon2011
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Categories: Englisch = English
Creators: Dixon, Halliday, Mason, Mohan, Norman, Reeve, Rybchyn, Sequeira
Collection: Cancer Prevention Research
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Popularity index: 7.5%
{Exposure to ultraviolet radiation (UVR) can lead to a range of deleterious responses in the skin. An important form of damage is the DNA photolesion cyclobutane pyrimidine dimer (CPD). CPDs can be highly mutagenic if not repaired prior to cell division and can lead to UV-induced immunosuppression, making them potentially carcinogenic. UVR exposure also produces vitamin D, a prehormone. Different shapes of the steroid hormone 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3] can produce biological responses through binding either to its cognate nuclear receptor (VDR) to regulate gene transcription or to the VDR associated with plasma membrane caveolae to produce, via signal transduction, nongenomic physiologic responses. Here, we show that both 1,25(OH)2D3 and 1α,25(OH)2-lumisterol (JN), a conformationally restricted analogue that can generate only nongenomic responses, are effective inhibitors of UV damage in an immunocompetent mouse (Skh:hr1) model susceptible to UV-induced tumors. Both 1,25(OH)2D3 and JN significantly reduced UVR-induced CPD, apoptotic sunburn cells, and immunosuppression. Furthermore, these compounds inhibited skin tumor development, both papillomas and squamous cell carcinomas, in these mice. The observed reduction of these UV-induced effects by 1,25(OH)2D3 and JN suggests a role for these compounds in prevention against skin carcinogenesis. To the best of our knowledge, this is the first comprehensive report of an in vivo long-term biological response generated by chronic dosing with a nongenomic-selective vitamin D steroid. Cancer Prev Res; 4(9); 1485–94. ©2011 AACR.}
Added by: Sarina  
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"This however does not mean that these myriad of photoproducts don’t have other biologic effects such as regulating epidermal cell growth and reducing risk of skin cancer. One product, lumisterol3 , if converted to 1,25-dihydroxylumisterol3 may have anti-tumor effects in the skin.37"

Added by: Sarina  Last edited by: Sarina
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