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Orlova, T. & Terenetskaya, I. (2020) UV Phototherapy: A New Look at the UV Sources and Doses. Clinics in Medicine, 2 5–8. 
Added by: Sarina (05 Sep 2022 11:56:33 UTC)   Last edited by: Sarina (05 Sep 2022 11:57:58 UTC)
Resource type: Journal Article
BibTeX citation key: Orlova2020
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Categories: Englisch = English
Keywords: Vitamin D = Vitamin D
Creators: Orlova, Terenetskaya
Collection: Clinics in Medicine
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Ultraviolet (UV) lamps are widely used in phototherapy, especially for the treatment of skin diseases. Although the positive effect of UV radiation is mainlyassociated with the synthesis of vitamin D in human skin, nevertheless, to avoid negative consequences, the determination of radiation doses is based on theerythemal activity of UV sources, and, as a rule, the initial doses are 0.5 - 1 MED. Moreover, although broadband UV lamps are known to be more productivefor the vitamin D synthesis, narrowband UV sources are preferred to minimize the negative effect of UV radiation on DNA. To find the missing link between theerythemal and ‘antirachitic’ UV doses we performed direct measurements of the erythemal activity and the vitamin D synthetic capacity of the two most usedUV lamps - broadband TL12 and narrowband TL01 (Philips). Erythemal doses were calculated from the spectroradiometer data, and antirachitic activity wasmeasured using an original method based on thein vitromodel of vitamin D synthesis. As expected, with an erythema dose of 1 SED (100 J/m2), the amount ofdirect precursor of vitamin D formed under the TL12 lamp was significantly higher than under the TL01 lamp. Thus, if the UV therapeutic effect is associatedwith the synthesis of vitamin D, then the time of UV irradiation with the TL12 lamp can be significantly reduced. These results show the feasibility of revising theconventional recommendations on UV light sources and doses in order to reduce negative UV effects.


Keywords: UV phototherapy; UV biodose; Erythema; Vitamin D synthesis; Provitamin D photoconversion; UV biodosimeter

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